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PostPosted: Tue Aug 21, 2012 8:34 am 
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So the researchers turned to a new idea: they picked a target in the virus that is less likely to change: an internal part, rather than the more traditional approach of picking something on the surface of the virus.


What part of the above do you not understand?


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PostPosted: Tue Aug 21, 2012 9:16 am 
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tommee wrote:
So the researchers turned to a new idea: they picked a target in the virus that is less likely to change: an internal part, rather than the more traditional approach of picking something on the surface of the virus.


What part of the above do you not understand?


I understand completely, that is the target, but what is the new MECHANISM to reach that target? Not the same processes previously used as you seem to claim, as they would not see a different outcome from the same process.

It is clear that you have no clue on what is being discussed by the papers or me.

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PostPosted: Tue Aug 21, 2012 9:51 am 
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The target was the new idea! You are a real penis.


So the researchers turned to a new idea: they picked a target in the virus that is less likely to change: an internal part, rather than the more traditional approach of picking something on the surface of the virus.

No connection.


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PostPosted: Tue Aug 21, 2012 10:27 am 
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tommee wrote:
The target was the new idea! You are a real penis.


So the researchers turned to a new idea: they picked a target in the virus that is less likely to change: an internal part, rather than the more traditional approach of picking something on the surface of the virus.

No connection.



So you are clueless. How do you change the target without changing the mechanisms used? (Hint: You cannot.)

The mechanisms between the two papers are the same thus the targets are also the same.

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PostPosted: Tue Aug 21, 2012 1:36 pm 
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Read the full paper then come back :-

No connection

What an idiot you are. #-o


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PostPosted: Tue Aug 21, 2012 3:32 pm 
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tommee wrote:
Read the full paper then come back :-

No connection

What an idiot you are. #-o


I have read the paper and unlike you understand what they are saying. I am sure you could find a bright high school senior that might be able to sit down and explain it to you until you understand it if you really try.

In the interim let me give you an example. If I am going to take a carburetor off of a motorcycle, I will use an appropriately sized wrench. Using a wrench which is larger or smaller than the attachment bolt will not work. If I wish to adjust that carburetor, I will use a screwdriver. Now if I try to use that screwdriver to remove the assembly I will be wasting my time, just as I would waste my time trying to make the adjustment with the wrench. The same applies to biology so the same virus/NS gene combination will not target the exterior or interior of Hep C just by declaring that is the intent. The virus/NS gene combo attacks the interior only. That is why both papers are connected.

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PostPosted: Wed Aug 22, 2012 5:32 am 
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the canadian study didn't target the inner nor did they use the flu virus or use the human/chimp ando combo.

no connection #-o


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PostPosted: Wed Aug 22, 2012 7:55 am 
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tommee wrote:
What an idiot you are. #-o


Tell us about your experience in molecular biology and virology.

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PostPosted: Wed Aug 22, 2012 7:55 am 
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tommee wrote:
the canadian study didn't target the inner nor did they use the flu virus or use the human/chimp ando combo.

no connection #-o


You know this how? Which specific adenoviruses and NS proteins were used? What was the target of the NS proteins and why were the adenoviruses used? You have no idea and will only try to make different claims based on your desire that chimps were not used in the development of this study.

Maybe you can just resort back to name calling, that really makes your case for you.

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PostPosted: Wed Aug 22, 2012 8:03 am 
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The second paper would represent the fine tuning of the process from the first paper resulting from the results of the earlier tests. That is how research progresses.

Non-structural genes = non-structural proteins

Adenoviruses = two adenoviruses

http://www.ncbi.nlm.nih.gov/pubmed/21198667

Encouraging efficacy data have been obtained in the hepatitis C virus (HCV) chimpanzee model using prophylactic vaccines comprising adjuvanted recombinant envelope gpE1/gpE2 glycoproteins or prime/boost immunization regimens using defective adenoviruses and plasmid DNA expressing non-structural genes.

http://www.medicalnewstoday.com/articles/239982.php

In their paper the researchers describe how they adapted two adenoviruses to carry NS (nonstructural) proteins from HCV genotype 1B. One adenovirus was sourced from a rare human serotype (Ad6, human adenovirus 6) and the other from chimpanzee (ChAd3, chimpanzee adenovirus 3).

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PostPosted: Wed Aug 22, 2012 10:35 am 
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Would, maybe...


no connection


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PostPosted: Wed Aug 22, 2012 11:45 am 
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tommee wrote:
Would, maybe...


no connection


Poor understanding of English:

would (wd)
aux.v. Past tense of will2

8. Used to express repeated or habitual action in the past: Every morning we would walk in the garden.


Clueless trolling now.

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PostPosted: Wed Aug 22, 2012 12:39 pm 
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Hadley the one whos clueless. You are the one clutching at straws, trying desperately to connect two studies that have no connection.

You have read abstracts that much is clear :-


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PostPosted: Wed Aug 22, 2012 12:54 pm 
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tommee wrote:
Hadley the one whos clueless. You are the one clutching at straws, trying desperately to connect two studies that have no connection.

You have read abstracts that much is clear :-


Who is Hadley?

I have read the abstracts and also discussed them with a PhD molecular biologist that used to work for me, a friend who is a molecular biologist working in childhood cancer research, and pharmaceutical researcher who lives next door to get a better understanding. All three agreed on the connection between the two paper's approach. How about you?

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PostPosted: Wed Aug 22, 2012 1:24 pm 
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Wayne Stollings wrote:
Clueless trolling now.


Been quite a while actually. :-

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