[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 483: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/bbcode.php on line 112: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead
[phpBB Debug] PHP Warning: in file [ROOT]/includes/functions.php on line 4688: Cannot modify header information - headers already sent by (output started at [ROOT]/includes/functions.php:3823)
[phpBB Debug] PHP Warning: in file [ROOT]/includes/functions.php on line 4690: Cannot modify header information - headers already sent by (output started at [ROOT]/includes/functions.php:3823)
[phpBB Debug] PHP Warning: in file [ROOT]/includes/functions.php on line 4691: Cannot modify header information - headers already sent by (output started at [ROOT]/includes/functions.php:3823)
[phpBB Debug] PHP Warning: in file [ROOT]/includes/functions.php on line 4692: Cannot modify header information - headers already sent by (output started at [ROOT]/includes/functions.php:3823)
EnviroLink Forum • View topic - Senate Committee passes bill to end chimp research

EnviroLink Forum

Community • Ecology • Connection
It is currently Wed Jul 26, 2017 8:41 am

All times are UTC - 5 hours [ DST ]




Post new topic Reply to topic  [ 123 posts ]  Go to page Previous  1 ... 3, 4, 5, 6, 7, 8, 9  Next
Author Message
PostPosted: Mon Aug 06, 2012 12:12 pm 
Offline
Member with 50 posts!
Member with 50 posts!

Joined: Fri Apr 13, 2012 1:07 pm
Posts: 188


Top
 Profile  
 
PostPosted: Mon Aug 06, 2012 1:02 pm 
Offline
EnviroLink Volunteer
EnviroLink Volunteer
User avatar

Joined: Thu Jun 26, 2003 10:45 pm
Posts: 21188
Location: Southeastern US

_________________
With friends like Guido, you will not have enemies for long.

“Intellect is invisible to the man who has none”
Arthur Schopenhauer


"The difference between genius and stupidity is that genius has its limits."
Albert Einstein


Top
 Profile  
 
PostPosted: Mon Aug 06, 2012 1:22 pm 
Offline
Member with 50 posts!
Member with 50 posts!

Joined: Fri Apr 13, 2012 1:07 pm
Posts: 188


Top
 Profile  
 
PostPosted: Mon Aug 06, 2012 1:51 pm 
Offline
Member with 50 posts!
Member with 50 posts!

Joined: Fri Apr 13, 2012 1:07 pm
Posts: 188
For more information please contact Professor Paul Klenerman on +44 (0)1865 281885, +44 (0)7769 861085 or paul.klenerman@medawar.ox.ac.uk

Or the University of Oxford press office on +44 (0)1865 280530 or press.office@admin.ox.ac.uk

No link pal :-


Top
 Profile  
 
PostPosted: Mon Aug 06, 2012 3:22 pm 
Offline
Member with over 1000 posts!
Member with over 1000 posts!
User avatar

Joined: Wed Mar 02, 2005 12:59 am
Posts: 2588
Location: Central Colorado
Does it all really matter when humans, if they don't reduce HGHGs enough, cause an ELE???

_________________
"With every decision, think seven generations ahead of the consequences of your actions" Ute rule of life.
“We do not inherit the earth from our ancestors; we borrow it from our children”― Chief Seattle
“Those Who Have the Privilege to Know Have the Duty to Act”…Albert Einstein


Last edited by Johhny Electriglide on Tue Aug 07, 2012 12:58 pm, edited 1 time in total.

Top
 Profile  
 
PostPosted: Mon Aug 06, 2012 3:22 pm 
Offline
EnviroLink Volunteer
EnviroLink Volunteer
User avatar

Joined: Thu Jun 26, 2003 10:45 pm
Posts: 21188
Location: Southeastern US

_________________
With friends like Guido, you will not have enemies for long.

“Intellect is invisible to the man who has none”
Arthur Schopenhauer


"The difference between genius and stupidity is that genius has its limits."
Albert Einstein


Top
 Profile  
 
PostPosted: Mon Aug 06, 2012 6:36 pm 
Offline
Member with 50 posts!
Member with 50 posts!

Joined: Fri Apr 13, 2012 1:07 pm
Posts: 188
"Viral vectors are a tool commonly used by molecular biologists to deliver genetic material into cells. This process can be performed inside a living organism (in vivo) or in cell culture (in vitro). Viruses have evolved specialized molecular mechanisms to efficiently transport their genomes inside the cells they infect. Delivery of genes by a virus is termed transduction and the infected cells are described as transduced. Molecular biologists first harnessed this machinery in the 1970s. Paul Berg used a modified SV40 virus containing DNA from the bacteriophage lambda to infect monkey kidney cells maintained in culture.[1]"

You would expect all studies in this field to use adenovirus vectors, it's a tool :lolno:


Top
 Profile  
 
PostPosted: Mon Aug 06, 2012 6:52 pm 
Offline
EnviroLink Volunteer
EnviroLink Volunteer
User avatar

Joined: Thu Jun 26, 2003 10:45 pm
Posts: 21188
Location: Southeastern US

_________________
With friends like Guido, you will not have enemies for long.

“Intellect is invisible to the man who has none”
Arthur Schopenhauer


"The difference between genius and stupidity is that genius has its limits."
Albert Einstein


Top
 Profile  
 
PostPosted: Tue Aug 07, 2012 4:56 am 
Offline
Member with 50 posts!
Member with 50 posts!

Joined: Fri Apr 13, 2012 1:07 pm
Posts: 188
Choosing a more constant internal virus part as a target would also stimulate a different type of immune response from what had been attempted in previous studies to develop an HCV vaccine.

".. we need T cells and not antibodies to be able to react to the inner components of the virus," said Klenerman.

So he and his colleagues set out to boost HCV-specific T cells using a "recombinant adenoviral vector strategy" in human volunteers. In total, 41 healthy adults took part in the study.

In their paper the researchers describe how they adapted two adenoviruses to carry NS (nonstructural) proteins from HCV genotype 1B. One adenovirus was sourced from a rare human serotype (Ad6, human adenovirus 6) and the other from chimpanzee (ChAd3, chimpanzee adenovirus 3).

The Oxford study also used a flu virus.

Cry me a river.

:-({|=


Top
 Profile  
 
PostPosted: Tue Aug 07, 2012 7:22 am 
Offline
EnviroLink Volunteer
EnviroLink Volunteer
User avatar

Joined: Thu Jun 26, 2003 10:45 pm
Posts: 21188
Location: Southeastern US

_________________
With friends like Guido, you will not have enemies for long.

“Intellect is invisible to the man who has none”
Arthur Schopenhauer


"The difference between genius and stupidity is that genius has its limits."
Albert Einstein


Top
 Profile  
 
PostPosted: Tue Aug 07, 2012 8:16 am 
Offline
Member with 50 posts!
Member with 50 posts!

Joined: Fri Apr 13, 2012 1:07 pm
Posts: 188


Top
 Profile  
 
PostPosted: Tue Aug 07, 2012 8:29 am 
Offline
EnviroLink Volunteer
EnviroLink Volunteer
User avatar

Joined: Thu Jun 26, 2003 10:45 pm
Posts: 21188
Location: Southeastern US

_________________
With friends like Guido, you will not have enemies for long.

“Intellect is invisible to the man who has none”
Arthur Schopenhauer


"The difference between genius and stupidity is that genius has its limits."
Albert Einstein


Top
 Profile  
 
PostPosted: Tue Aug 07, 2012 3:03 pm 
Offline
Member with 50 posts!
Member with 50 posts!

Joined: Fri Apr 13, 2012 1:07 pm
Posts: 188
Michael Houghton, Ph.D., Canada Excellence in Research Chair and Professor, Medical Microbiology & Immunology, University of Alberta
"We can be optimistic about HCV vaccine development based on 1) the demonstration of significant natural immunity in the chimpanzee challenge model and in man, 2) the identification of cellular and humoral correlates of immunity, 3) the demonstration of vaccine efficacy in the chimpanzee challenge model & 4) the recent demonstration of a vaccine able to elicit broadly cross-neutralising antibodies against all major, global genotypes. Current vaccine candidates in clinical development elicit either broad, cross-reactive cellular immune responses or broad, cross-neutralizing antibody responses but combining both is likely to result in at least a partially effective vaccine against this highly heterogeneous virus that is estimated to infect many hundreds of thousands each year around the globe. "

Example

Candidate HCV vaccines have shown limited efficacy in clinical trials. Neutralizing antibodies (NAbs) are a key component of all licensed vaccines. In HCV infection, NAbs are primarily directed to the major surface glycoprotein E2 and have been correlated with viral clearance. However, most HCV specific NAbs are directed to the hypervariable region 1 (HVR1), which are type-specific as the name suggests. By contrast, NAbs directed to the HCV receptor (CD81) binding site show the capacity to mediate broad neutralization, but these antibodies are rarely produced in the presence of the immunodominant HVR1. We have investigated how different oligomeric forms of Δ123 E2 (monomer, dimer and higher order forms) induce different levels of neutralizing antibodies.

http://www.imvacs.com/novel-vaccines


Oxford study

""Both vectors primed T cell responses against HCV proteins; these T cell responses targeted multiple proteins and were capable of recognizing heterologous strains (genotypes 1A and 3A)."

""The outside shell of the hepatitis C virus is very variable but the inside of the virus is much more stable. That's where the engine of the virus is, where we may be able to successfully target many of the crucial pieces of machinery."

Choosing a more constant internal virus part as a target would also stimulate a different type of immune response from what had been attempted in previous studies to develop an HCV vaccine.

.. we need T cells and not antibodies to be able to react to the inner components of the virus," said Klenerman."

Canada

"Houghton, also the Li Ka Shing Chair in Virology at the University of Alberta, says the vaccine, developed from a single strain, has shown to be effective against all known strains of the virus. It took more than 10 years to develop and started while he was working for the drug company Novartis. Following previous vaccine tests funded by the National Institutes of Health that yielded promising results, he said there remained two critical questions."


"The challenge, Houghton said, was that hepatitis C is more virulent than HIV, thus coming up with a vaccine that would neutralize the different strains around the world was believed to be impossible. Using a vaccine developed and tested on humans in his University of Alberta lab, Houghton and his co-investigator John Law discovered that the vaccine was capable of eliciting broad cross-neutralizing antibodies against all the different major strains. Houghton says that this finding bodes good news for those with hep C and those who live or travel to areas where the disease is prevalent."

http://www.hepctrust.org.uk/News_Resour ... +C+Vaccine



Please do link the studies #-o


Top
 Profile  
 
PostPosted: Tue Aug 07, 2012 3:38 pm 
Offline
EnviroLink Volunteer
EnviroLink Volunteer
User avatar

Joined: Thu Jun 26, 2003 10:45 pm
Posts: 21188
Location: Southeastern US

_________________
With friends like Guido, you will not have enemies for long.

“Intellect is invisible to the man who has none”
Arthur Schopenhauer


"The difference between genius and stupidity is that genius has its limits."
Albert Einstein


Top
 Profile  
 
PostPosted: Tue Aug 07, 2012 3:51 pm 
Offline
Member with 50 posts!
Member with 50 posts!

Joined: Fri Apr 13, 2012 1:07 pm
Posts: 188
#-o


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 123 posts ]  Go to page Previous  1 ... 3, 4, 5, 6, 7, 8, 9  Next

All times are UTC - 5 hours [ DST ]


Who is online

Users browsing this forum: No registered users and 3 guests


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Jump to:  
cron
Powered by phpBB® Forum Software © phpBB Group