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PostPosted: Tue Aug 07, 2012 5:00 pm 
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One of the more understandable replies from you. Does that mean you understand your poor position?

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PostPosted: Sun Aug 19, 2012 1:43 pm 
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If you think that none structural proteins is a link you are sadder than I thought.

There is no connection. you know it, I know it. Not even funded by the same groups :lolno:


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PostPosted: Sun Aug 19, 2012 4:13 pm 
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tommee wrote:
If you think that none structural proteins is a link you are sadder than I thought.

There is no connection. you know it, I know it. Not even funded by the same groups :lolno:



That would be an integral part of the new appraoch now would it not? Either it is not such a novel approach or the two are connected. That means either they are not being truthful about the approach being so non-traditional or you are wrong in assuming there can be no connection. According to Occam's razor, you are the more likely candidate to be wrong rather than the people speaking of their own work.

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PostPosted: Mon Aug 20, 2012 4:59 am 
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So the researchers turned to a new idea: they picked a target in the virus that is less likely to change: an internal part, rather than the more traditional approach of picking something on the surface of the virus.

No connection :crazy:


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PostPosted: Mon Aug 20, 2012 7:05 am 
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tommee wrote:
So the researchers turned to a new idea: they picked a target in the virus that is less likely to change: an internal part, rather than the more traditional approach of picking something on the surface of the virus.

No connection :crazy:


What did they USE to target that internal part? The SAME non-structural proteins and viral transmitters. If you can get someone with a grasp of biology to explain that to you we would not have to see you try to pick small segments out to try to claim the lack of connection when the overall claims are the same.

Non-structural genes = non-structural proteins

Adenoviruses = two adenoviruses

http://www.medicalnewstoday.com/articles/239982.php

In their paper the researchers describe how they adapted two adenoviruses to carry NS (nonstructural) proteins from HCV genotype 1B. One adenovirus was sourced from a rare human serotype (Ad6, human adenovirus 6) and the other from chimpanzee (ChAd3, chimpanzee adenovirus 3).

http://www.ncbi.nlm.nih.gov/pubmed/21198667

Encouraging efficacy data have been obtained in the hepatitis C virus (HCV) chimpanzee model using prophylactic vaccines comprising adjuvanted recombinant envelope gpE1/gpE2 glycoproteins or prime/boost immunization regimens using defective adenoviruses and plasmid DNA expressing non-structural genes.

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PostPosted: Mon Aug 20, 2012 8:21 am 
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It's a common starter in this field.

No connection :crazy:


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PostPosted: Mon Aug 20, 2012 8:43 am 
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tommee wrote:
It's a common starter in this field.

No connection :crazy:


A common starter? So you are saying their new and non-traditional approach was not new or non-traditional, but "common" now? You honestly cannot have it both ways. The viral carrier of the non-structural proteins is how they targeted the interior rather than the exterior according to their papers. Now you are saying they mislead us in that regard?

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PostPosted: Mon Aug 20, 2012 10:58 am 
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Your idea of a new approach, the approach was where they targeted by boosting T cells. Usual approach was to target the outer layer, boost anti bodies etc [-X

No connection, different funding and no citation of each other.

Keep plucking.


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PostPosted: Mon Aug 20, 2012 11:23 am 
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tommee wrote:
Your idea of a new approach, the approach was where they targeted by boosting T cells. Usual approach was to target the outer layer, boost anti bodies etc [-X

No connection, different funding and no citation of each other.

Keep plucking.


That is what the viral/non-structural protein approach did, the combination was to target the interior portions, not the normal external approach. If they used the same viral/non-structured gene approach for the inside and outer portions, how was it different?

The two papers were part of different studies related to the same basic research. The later clinical trials can have some different people and funding sources as well. The clinical trial would not have a reason to reference the prior research that was not clinical in nature and the prior research could not cite future research.

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PostPosted: Mon Aug 20, 2012 11:56 am 
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Keep plucking.


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PostPosted: Mon Aug 20, 2012 12:14 pm 
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tommee wrote:
Keep plucking.


Yes, trying to get you to see that the same process will not give to different and distinct results so they must be connected is difficult when you really do not want to understand because that would involve admission of the truth about chimp testing.

Ignorance may be bliss but it is also evident in your approaches.

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PostPosted: Mon Aug 20, 2012 1:42 pm 
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So link it instead of guessing :-


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PostPosted: Mon Aug 20, 2012 1:50 pm 
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tommee wrote:
So link it instead of guessing :-


How is showing they used the same procedures guessing? You are the one jumping from the procedure being common to then being a new approach as an attempt to make the point of the minute seem real.

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PostPosted: Tue Aug 21, 2012 3:39 am 
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You are the one pointing out the use of nonstructural proteins is the new approach, no I, fact is it isn't.

No link :-


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PostPosted: Tue Aug 21, 2012 6:30 am 
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tommee wrote:
You are the one pointing out the use of nonstructural proteins is the new approach, no I, fact is it isn't.

No link :-


It isn't? Then pray tell what IS the new approach then? The use of adenoviruses? The use of adenoviruses to carry NS proteins? That is the extent of the options available from the papers detailing their non-traditional approach.

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