http://www.iaapea.com/fatalmistakes_page.php?id=10Animal Tests Cannot Predict What Will Happen with New Medicines
Examples of Adverse Drug Reactions since Thalidomide
(not predicted by animal experiments16 )
Aminorex pulmonary hypertension
Benoxaprofen fatalities, phototoxicity
Chloramphenicol aplastic anaemia
Clindamycin intestinal disease
Clioquinol neurotoxicity
Domperidone cardiotoxicity
Halothane jaundice
Isoprenaline aerosol inhalers asthmatic deaths
Ketoconazole liver damage
Methysergide retroperitoneal fibrosis
Oral contraceptives
Phenylbutazone blood clots
Practolol aplastic anaemia
Prenylamine eye, skin and abdominal toxicity
Stilboestrol vaginal cancer in female offspring
Suprofen kidney dysfunction, side pain
Tycrynafen cardiotoxicity
Zimediline neurotoxicity
In most cases, animal tests cannot predict what will happen when a new medicine is given to people.17 But the tests not only give a false sense of security, there is also the risk that worthwhile therapies may be lost or delayed through toxic effects that do not occur in human beings. A review of 45 drugs by Britain’s Committee on Safety of Medicines found that animal experiments were most likely to predict vomiting and gastrointestinal disturbances. Overall, however, the survey found that, at best, just 25% of the harmful effects observed in animals actually occurred in people.18
http://www.iaapea.com/101.phpDr Robert Sharpe was a Senior Research Chemist at the prestigious Royal Postgraduate Medical School in London when he found himself at odds with colleagues who tested his chemicals on animals. He resigned his position and began to investigate, what until then he had taken for granted, that animal experiments were vital for medical progress.
1.Transplant Drug almost Lost
2.Leukemia and the Nuclear Industry
3.Migraine Pill's Horrific Side Effect
4.Suprofen Joins Band List
5.Animal Mix Deadly Cocktail of Confusing Results
6.Pesticide Poisonings
7.Arsenic and the Decades of Failure
8.Rodent Tests Miss Industrial Cancer Risk
9.Valuable Eye Therapy Would Not Pass Rabbit Test
10.Rabbit Test Misses Human Eye Irritant
11.Slimming Treatment Caused Cataracts
12.Shock Treatment
13.Body Chemicals Produce Opposite Effects in Animals
14.Blood Pressure Pill Leads to Withdrawal Syndrome
15.Drug Induced Disaster Leaves Thousands Dead
16.Animal Tests Confuse Painkiller Probe
17.Diarrhoea Treatment Leaves 10,000 Victims
18.Women at Risk from Pill Safety Tests
19.Safe Antibiotics Fatal Flaw
20.Doctors Warned about Halothane Liver Toxicity
21.Cancer-Prone Mice Contradict Human Experience
22.Vivisection Undermines Miners Welfare
23.Animal Skin Test not up to Scratch
24.Monkey Experiments put Malaria Patients at Risk
25.Blood Cell Damage missed by Animal Testing
26.Dog Research Undermines Heart Valve Research
27.Animal Tests Used to Promote Superior Arthritus Drug
28.Fatal Diuretic Seemed Safe
29.Angina Drugs Fatal Effects
30.Menthol and Eye Irritation
31.Non-Toxic Ointment Proves Dangerous
32.Safe Cleaning Agents Damage Animal Victims
33.Morphine Madness
34.Chemotherapy Aid Withdrawn
35.Natural Skin Substance Harms Animals
36.Heart Treatment Withdrawn
37.Doctors Warn Against Safe Eye Treatment
38.Animal-Testes Arthritis Drugs Killed Thousands
39.The Chloroform Controvosy
40.Anaemia Cure Fails in Animals
41.Research 'Paralyzed' by Animal Models
42.Anti-Cancer Hope Abandoned
43.Unexpected Eye Problems Led to Drug Rejection
44.Corticosteroids & Birth Defects
45."Harmless" Antidepressant Damaged Liver
46.Thalidomide
47.Beagle Dogs Mislead Cancer Research
48."Harmless" Ulcer Drug Could Cause Heart Failure
49.Antibiotic's Deadly Side-Effect
50.Leukemic Mice Fail Cancer Patients
51.The First Beta-Blockers
52.Minor Tranquillizers Produce Major Problems
53.Rifampcin & The Pill
54.Breast Cancer Drug Overcomes Conflicting Data
55.Steroids & the Immune System
56.X-Rays & Cancer
57.The Methanol Scandal
58.Obesity Drug's Horrific Side Effects
59.Daughters of DES
60.Heart Drug Fears Groundless
61.Pethidine Addiction
62."Safe" Eye Solutions Fail the Human Test
63.Toxic Treatments
64.Animals and Aids
65.Useful Therapies at Risk from False Animal Data
66.Transplant Drug Causes Unexpected Kidney Damage
67.Animal Tests mask Nerve Damage Risk
68.Cough Remedy Leaves Overdose Patients in Coma
69.nine Species Fails to Predict Liver Damage
70.Animal Victims Escalate after ICI Drug Fails
71.Liver Damages not Predicted... Again!
72.Animals Starve in Brain Research Fiasco
73.The Practolol Syndrome
74.Animals Miss Steroid Eye Risk
75.Babies at Risk from Talc
76.Animal Test Minimise Riot Gas Hazard
77.Lab Rats Raise False Fears Over Water Treatment
78.Natural Flavouring banned After Misleading Animal Data
79.Inhalations Test throw False Doubt on Formaldehyde
80.Epilepsy Model Give Fitful Results
81.Workers at Risk fri=om Misleading Animal Tests
82.Dog Deaths Deny Women Contraceptive Option
83.Useless Treatment Poisons Workers
84.Piosoning Tests Offer Little Hope to Overdose Patients
85.Animal Diet Studies Contradict Human Colon Risks
86.Cancer Cure Delayed by False Animal Data
87.Monkey Experiments Delay Polio Breakthrough
88.Antibiotics, Guinea Pigs & Hamsters
89.Animals Divert Attention from Cancer Prevention
90.The Dogma of Death
91.The Opren Affair
92.Laboratory Animals Fail Stroke Victims
93.Flexible Animal Test Support Rival Theories
94.Heart Drugs May Have Killed 3,000
95.Rats Cast Doubt on Olive Oil!
96.Bleach Highlights Faulty Skin Test
97.Smoking Dangers Masked by False Animal Data
98.Tragedy of the Killer Dust
99.Transplant Research Misdirected
100.Drug Danger Undetected
101.Tragedy Hits Hepatitis Victims